Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.

The Pten and Tsc1 genes both Ski de fond - Skis a roulettes encode proteins that repress mechanistic target of rapamycin (mTOR) signaling.Disruption of either gene in the brain results in epilepsy and autism-like symptoms in humans and mouse models, therefore it is important to understand the molecular and physiological events that lead from gene d

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Lessons learned after one year of COVID-19 from a urologist and radiotherapist view: A German survey on prostate cancer diagnosis and treatment

Introduction Since the beginning of the pandemic in 2020, COVID-19 has changed the medical landscape.International recommendations for localized prostate cancer (PCa) include deferred treatment and adjusted therapeutic routines.Materials and methods To longitudinally evaluate changes in PCa treatment strategies in urological and radiotherapy depart

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RNase R, a New Virulence Determinant of Streptococcus pneumoniae

Pneumococcal infections have increasingly high mortality rates despite the availability of vaccines and antibiotics.Therefore, the identification of new virulence determinants and the understanding of the molecular mechanisms behind pathogenesis have become of paramount importance in the search of new targets for drug Detox Products development.The

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Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

Abstract In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged STRUCTURE MASK cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity.Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical tria

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